On 1st May 2020 The US Foods and Drugs Administration issued an authorization for use of Remdesivir an experimental anti- viral drug. With this doctors can now be able to treat those patients who have severe symptoms of COVID-19.
Remdesivir is not a new drug. Initially it was developed to treat RSV and Hepatitis C a respiratory infection causing virus. Much like COVID-19 it was also used in treatment of two other coronavirus like MERS and SARS and also for treating Ebola.
Unfortunately it could not be used then as it never reached to the approval stage. Desperate to find to find cure and to mitigate the coronavirus scientist are now looking for old drugs which could be repurposed. It is as in that Ramdesivir has time traveled in its path towards approval and became the most promising drug in the COVID-19 treatment.
But Ramdesivir cannot treat or cure COVID-19 rather it works by other way around. It works by attacking the vrius once it spreads within the body. Below it is explained how Remdesivir works.
Step No 1: When Virus Enters Your Cell.
In order to multiply virus needs to bind with cell protein. So they first enter into the healthy cell. Cornavirus which caused COVID-19 have spikes protein on its outer shell which helps them to bind cells.
Step No2: Release Genetic Code.
Like a blueprint once inside the virus releases a strand of RNA (Rebunucleic Acid) and fuses with the cell. This RNA has a strings of codes which produces exact copies of the virus.
Step No 3: Converting Genetic Code into Protein
Tiny particles inside the host cells called ribosomes are equipped to read to read genetic material. Ribosomes passes viral protein when RNA passes through this ribosomes.
Step No 4: Making Copies
Virus proteins are needed to make Viral RNA copies which also products copies of the virus outer part like the membrane and spikes. More the copies of RNA and strands are made more the copies fill up the cell exponentially.
Step No 5: Assembly of Viral Parts.
The Virus uses a mechanism inside the host cell to come together in order to form a complete Virus. Once assembled this virus exits the cell and further attack another cell.
Step No 6: Role of Remdesivir (Blocks the replication.)
Mimicking a part of viral RNA during the coping process Remdesivir inserts itself in the strand. The drug prevents any further coping of the virus once attached which leaves the virus incomplete and unable to produce any vital part.
Step No 7: Slowing Down.
Hampered by the drug the replication process slows down. This means fewer virus gets assembled which are incomplete or defective with partial RNA which cannot replicate itself into another cell.
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